Cats, dogs, etc all know when sickness is around. They are scared of, or try to attack other animals with, say, rabies, or distemper. Often, they will attack or try to avoid unstable or mad (insane in this meaning) creatures. When their instincts tell them something is wrong, or dangerous about another creature, they are ALWAYS accurate. They have good survival instincts.
It would be REALLY interesting to see how a pod of dolphins would respond to the trans wife.
So. Just saying.